I use a Wacom Intuos 2 with DataCAD at home. I have the pen tip set to the default Left-Click, one button set for Middle-Click, and one button set to Right-Click and this seems to work pretty well with DataCAD. The only real disadvantage that I've seen is the lack of a wheel for zooming.
What I would really like to eventually get is the Cintiq 21UX:
http://www.wacom.com/cintiq/cintiq-21ux.php
I know that there are a few others on this forum that use various tablets from Wacom. Do you have any specific questions?